SS31

PEPTIDES

SS-31 (Szeto-Schiller-31), also known as MTP-131, is a tetrapeptide that has garnered interest for its potential properties related to mitochondrial dysfunction.

12345@Ursofik.com

Inquire Now

Description

SS-31 Research

SS-31 (also called elamipretide) is a peptide that specifically targets mitochondria. Clinical evidence indicates that SS-31 demonstrates promise in addressing numerous medical conditions stemming from mitochondrial dysfunction.

SS-31 Mechanisms of Action
SS-31 operates within cells by selectively aggregating inside the inner mitochondrial membrane, where it binds to cardiolipin, a critical component of mitochondrial structure and function. By binding to cardiolipin, SS-31 helps maintain the shape of the mitochondria’s inner folds, known as cristae, which facilitates their energy-producing capabilities.

SS-31 also functions as a potent antioxidant, neutralizing damaging reactive oxygen species (ROS). This action helps to prevent oxidative stress and maintain mitochondrial function.

Further, SS-31 promotes the flow of electrons through the mitochondrial respiratory chain, which boosts ATP production – the cell’s energy currency.

Lastly, SS-31 has been shown to prevent cell death by inhibiting the activation of pro-apoptotic proteins and preserving mitochondrial integrity.

SS-31 and Mitochondrial Dysfunction

Mitochondria are known as “powerhouses” within cells and play a critical role in energy production while maintaining overall cellular homeostasis. When their internal membrane components become compromised, such as cardiolipin, it can result in a cascade of detrimental health effects. SS-31 is a mitochondria-targeting peptide and has shown promising results in addressing mitochondrial dysfunction across various studies.

SS-31 has been found to protect and restore mitochondrial structure, including lengthening mitochondria and restoring cristae membrane structure in kidney disease contexts. It also promotes ATP synthesis, reduces electron leakage, and prevents cardiolipin peroxidation, required for maintaining the inner mitochondrial membrane’s normal structure.

In models of mitochondrial cardiomyopathy, SS-31 reversed mitochondrial fragmentation and improved mitochondrial structure and function in patient-derived fibroblasts [R]. SS-31 has also shown promise in improving mitochondrial dysfunction and cognitive impairments in mice models of inflammation-induced cognitive decline.

SS-31 and Kidney Disease

SS-31 has demonstrated renoprotective effects, showing promise in treating kidney diseases. It has been found to reduce indicators of inflammation, oxidative stress, and cell proliferation in kidney disease models. Specifically, SS-31 treatment has shown to decrease proteinuria, mesangial expansion, and podocyte deficiency, suggesting its protective effects against renal diseases are significant.

SS-31 and Cardiac Dysfunction

In models of cardiac mitochondrial dysfunction, SS-31 has shown beneficial effects by improving mitochondrial structure and function, increasing energy production, and reducing ROS generation. It has been particularly effective in treating cardiomyopathy in Barth Syndrome (BTHS) patients, improving exercise tolerance, muscle strength, and certain cardiac parameters.

SS-31, Cancer and Chemotherapy-Induced Cachexia

SS-31 has been effective in ameliorating the whole body energy status in cancer- and chemotherapy-induced cachexia. It partially relieved body weight loss without interfering with tumor growth and improved muscle energetics. Increasing SS-31 dosage was found to be more effective at intermediate time points before the onset of refractory cachexia.

SS-31, Oxidative Stress and Autophagy

SS-31 ameliorates oxidative stress by restoring autophagic flux, which protects aged mice from hind limb ischemia. It reduces oxidative stress and improves skeletal muscle structure and function, suggesting it could be a new treatment strategy for peripheral artery disease (PAD).

SS-31 and Diabetes

SS-31 increases SIRT1 levels and ameliorates inflammation, oxidative stress, and leukocyte-endothelium interactions in type 2 diabetes. It reduces the risk of cardiovascular diseases in T2D patients by improving mitochondrial function and inhibiting mitochondrial permeability transition

We have cooperated with experienced shipping forwarders for many years, they arrange the shipment. No matter by express, by air or by sea, we will track the course of the goods all the way, to make sure goods arrive at you on time and in good condition.

Previous
SURVODUTIDE

Next
SNAP-8

GET A QUOTE

Whether you have any questions about our products, please feel free to contact us, we will reply as soon as possible.

Melanotan 2

Mechanism of Action: Melanotan II is an agonist of melanocortin receptors 1 and 4 (MC-1R and MC-4R), which respectively regulate melanin production and male erectile function. It is also believed to stimulate MC-3R, which affects appetite and energy levels. Notable Studies: · Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study · Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan 2 · An unhealthy glow? A review of Melanotan use and associated clinical outcomes What is Melanotan 2? Melanotan 2 is a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH). The molecule was first developed in the 1980s by University of Arizona researchers, who were looking to clarify the nature and role of the melanocortin receptors in physiological functions. Namely, the peptide was intended to be used as a sunless tanning agent, but was subsequently found to strongly affect sexual function and appetite . Melanotan 2 (MT-II) should not be confused with another ...

TB-500

What is TB-500? TB-500 is a 43 amino acid synthetic analog of thymosin B-4 (TB-4), which occurs naturally in nearly all mammalian cells. TB-500 is known for its effects on actin, cell migration, and wound healing. Animal models and in vitro studies have shown that TB-500 can improve blood vessel growth, accelerate wound healing, reduce inflammation, and promote production of extracellular matrix. The peptide is currently being studied for its ability to reduce oxidative stress in spinal cord injuries, improve recovery after heart attacks, and have a variety of anti-aging effects. TB-500 Mechanism of Action TB-500 is the active domain of TB-4 and primarily acts as an actin-binding protein. Actin is an important component of cellular structure and makes up microfilaments. Microfilaments are responsible for giving cells their shape, protecting the integrity of cell membranes, allowing cells to move/migrate, and certain steps in cell reproduction. Actin is also one of the main components of muscle protein. Without actin, muscles cannot contract. Actin-binding proteins such as TB-4 sequester actin monomers (single units of actin), thereby protecting them from degradation and allowing them to polymerize into microfi ...

OXYTOCIN

What is oxytocin? The peptide hormone is made up of 9 amino acids. It is produced in the hypothalamus, an area of the brain that controls heart rate, blood pressure, and digestion. OT is released into the bloodstream by the posterior pituitary gland. Oxytocin was discovered by Sir Henry Dale in 1996. He found that extracts from the posterior pituitary gland of humans caused the uterus of pregnant cats to contract. Sir Henry Dale also coined the name oxytocin, which means "quick labor" in Greek. This peptide hormone controls many functions. It has an impact on labor, milk secretion during breastfeeding, and bonding with newborns in humans. It also plays an important role in sexual arousal, romantic attachment, and other social interactions. It is also known as the "love hormone." A 2012 study found that levels of this hormone were significantly higher in newly-in-love people than in singles. The findings suggest that it may play an important role in the initial stages of a relationship. Pure Rawz sells this product for research use only. How does oxytocin work? Research suggests that it interacts with neural pathways responsible for processing motivation-related stimuli. In particular, ...

IPAMORELIN

Compound Class: Peptide Mechanism of Action: Ipamorelin is a selective growth hormone secretagogue and ghrelin receptor agonist that triggers and stimulates growth hormone production by mimicking ghrelin. It binds to ghrelin receptors, stimulating growth hormone release, and inhibits somatostatin and suppresses its effects. Notable Studies: · Ipamorelin, the first selective growth hormone secretagogue · The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced reductions in bone formation in adult rats · The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats What is ipamorelin? Ipamorelin is a laboratory-made compound known as growth hormone-releasing peptide. It stimulates the body to release growth hormone, which promotes systemic growth of muscle, bone, vascular system, and other cells and body tissues. Ipamorelin is unique among growth hormone-releasing peptides in that, unlike most growth hormone-releasing peptides, it does not activate the body's natural stress response. This gives ipamorelin an advantage over similar compounds. However, researc ...

MOTS-C

Class of Compound: Peptide Mechanism of Action: While the precise mechanism of action of MOTS-c is currently under investigation, it is hypothesized that its metabolic effects are mediated through its translocation to the nucleus and subsequent activation of AMPK. Notable Studies: · MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction. · The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. · MOTS-c Functionally Prevents Metabolic Disorders. Metabolites. What is MOTS-c? MOTS-c , is a mitochondrial-derived peptide, consisting of 16 residues encoded by the 12S rRNA region of the mitochondrial genome. This means that the genetic information that is translated into the peptide’s amino acid sequence has not been processed into a strip of mRNA. Rather, the peptide is translated from a strand of rRNA whose main role is not to carry genetic information but to help ribosomes work in processing such information. MOTS-cwas discovered in 2015 and has s ...

We Provide Best Services
Agent

Email For Us

Call For Us

SS31

12345@Ursofik.com

Previous
SURVODUTIDE

Next
SNAP-8

GET A QUOTE

Categories

Hot products

Melanotan 2

TB-500

OXYTOCIN

IPAMORELIN

MOTS-C

New Products

Follow Us

Useful Link

Products

Newsletter

Contact Us

SS31

SURVODUTIDE

SNAP-8

GET A QUOTE

Related products

Categories

Hot products

New Products

Useful Link

Products

Contact Us

GET IN TOUCH!