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What is Tesamorelin? Tesamorelin is a stabilized synthetic analogue of Growth Hormone Releasing Hormone (GHRH),not specifically from the hypothalamus, used for the reduction of excess abdominal fat in HIV-patients with lipodystrophy. Lipodystrophy is a metabolic condition often associated with insulin resistance, fat redistribution, and hyperlipidemia associated with antiretroviral therapy for the treatment of HIV infection. Mechanism of Action Tesamorelin works by mimicking the natural Growth Hormone Releasing Hormone, stimulating the pituitary gland to release more growth hormone. This increase in growth hormone leads to various metabolic effects, majorly the reduction of excess abdominal fat, and helps improve body composition. By binding to GHRH, Tesamorelin causes a series of physiological reactions that result in a reduction of visceral fat in the abdominal area. Potential Benefits of Tesamorelin The following are the benefits of Tesamorelin: Fat loss and improvement in body composition: One of the well-known benefits of tesamorelin is the visceral fat reduction. Research shows that tesamorelin may help in the reduction of excess abdominal fat and also help improve the body compo ...
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What is TB-500? TB-500 is a 43 amino acid synthetic analog of thymosin B-4 (TB-4), which occurs naturally in nearly all mammalian cells. TB-500 is known for its effects on actin, cell migration, and wound healing. Animal models and in vitro studies have shown that TB-500 can improve blood vessel growth, accelerate wound healing, reduce inflammation, and promote production of extracellular matrix. The peptide is currently being studied for its ability to reduce oxidative stress in spinal cord injuries, improve recovery after heart attacks, and have a variety of anti-aging effects. TB-500 Mechanism of Action TB-500 is the active domain of TB-4 and primarily acts as an actin-binding protein. Actin is an important component of cellular structure and makes up microfilaments. Microfilaments are responsible for giving cells their shape, protecting the integrity of cell membranes, allowing cells to move/migrate, and certain steps in cell reproduction. Actin is also one of the main components of muscle protein. Without actin, muscles cannot contract. Actin-binding proteins such as TB-4 sequester actin monomers (single units of actin), thereby protecting them from degradation and allowing them to polymerize into microfilament ...
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Key Features: Wrinkle Reduction: Effectively reduces expression lines and wrinkles. Botulinum Toxin Alternative: Provides a safer, non-invasive alternative to traditional botulinum toxin treatments. Skin Smoothness: Improves skin texture and smoothness. Anti-Aging: Reduces signs of aging and maintains a youthful appearance. Research Support: Studies have shown it to be effective in reducing the depth and formation of wrinkles. Description SNAP-8 is a natu rally derived, non-toxic, non-invasive peptide that has been shown to have the potential to reduce facial wrinkles and improve skin appearance. It is an extension of the hexapeptide ARGIRELINE, known for its ability to modulate muscle contraction, thereby reducing the formation of fine lines and wrinkles. Structure and Modifications SNAP-8 is an octapeptide composed of glutamyl and heptapeptide amino acids. Its structure allows it to mimic the N-terminus of SNAP-25, a protein involved in the SNARE complex, which is essential for neurotransmitter release and muscle contraction. Synthesis and Studies SNAP-8 has been synthesized using a variety of methods, including solid phase synth ...
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How does Retatrutide work? Retatrutide may function by activating multiple receptors, including those for glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon. This multi-receptor activity could lead to enhanced insulin secretion, reduced appetite, and increased energy expenditure. The compound is being studied for its potential influence on the central nervous system, gastrointestinal tract, and peripheral tissues. and peripheral tissues. Potential Benefits of Retatrutide Studies on Retatrutide suggest that it may offer a variety of potential benefits, including: Weight Management: By potentially reducing appetite and increasing energy expenditure, Retatrutide may help manage weight. Improving Glycemic Control: The compound may enhance insulin secretion and sensitivity, helping to better regulate blood sugar. Lipid Metabolism: Retatrutide peptides can affect lipid metabolism, potentially reducing lipid levels and improving cardiovascular health markers. Broad Metabolic Effects: Due to Retatrutide's multi-receptor effects, it may offer a wide range of metabolic benefits to ...
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Description PT-141, also known as bremelanotide, is an innovative new peptide hormone therapy for men and women that improves sexual function. PT-141 is an effective and highly effective treatment for erectile dysfunction and increased libido in men, and for improving sexual arousal disorders in women. PT 141 peptide gives you desire and drive while increasing blood flow to the penis or vagina and clitoris, restoring intimacy and passion to your relationship. PT 141 addresses these issues and helps resolve sexual difficulties. PT-141 works directly through the nervous system to increase arousal, desire, and sexual satisfaction. Drugs such as Viagra and Cialis work through the vascular system and only give you an erection. However, PT-141 not only gives you an erection, it also gives you desire and drive, restoring intimacy and passion to your relationship. Benefits of PT 141 PT 141 works by stimulating melanocortin receptors in the brain. It can be injected subcutaneously or inhaled through the nose to treat sexual dysfunction. It is known to work quickly, usually in less than an hour. This peptide can offer many benefits to men and women with decreased libido and sexual performance. Trea ...
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What is PEG-MGF peptide? PEG MGF, short for PEGylated mechano-growth factor, is a two-component anabolic peptide. PEG MGF is a well-known derivative of the compound insulin-like growth factor-1 (IGF-1). IGF-1 is thought to play an important role in the regulation of growth hormone (GH). In addition, this chemical may also help promote bone and tissue growth. PEG MGF promotes muscle growth by prompting various receptors to drive myoblasts to divide. Several studies have also shown that PEG MGF can increase the number of muscle stem cells that bind to existing muscle cells, thereby promoting muscle growth. PEG MGF has a short half-life of about 5 to 7 minutes. To address this, this experimental chemical is PEGylated. PEGylation is performed by adding polyethylene glycol (PEG) to the peptide. By adding the PEG group, the half-life of MGF can be safely and effectively extended to 48-72 hours. Possible Applications of PEGylated Mechano-Growth Factor Peptides: PEG MGF Peptides and Bone Repair In the animal model mouse, MGF treatment improved the migration of chondrocytes (cells responsible for cartilage formation) from the bone to the cartilage where they are needed. PEG ...
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What is oxytocin? The peptide hormone is made up of 9 amino acids. It is produced in the hypothalamus, an area of the brain that controls heart rate, blood pressure, and digestion. OT is released into the bloodstream by the posterior pituitary gland. Oxytocin was discovered by Sir Henry Dale in 1996. He found that extracts from the posterior pituitary gland of humans caused the uterus of pregnant cats to contract. Sir Henry Dale also coined the name oxytocin, which means "quick labor" in Greek. This peptide hormone controls many functions. It has an impact on labor, milk secretion during breastfeeding, and bonding with newborns in humans. It also plays an important role in sexual arousal, romantic attachment, and other social interactions. It is also known as the "love hormone." A 2012 study found that levels of this hormone were significantly higher in newly-in-love people than in singles. The findings suggest that it may play an important role in the initial stages of a relationship. Pure Rawz sells this product for research use only. How does oxytocin work? Research suggests that it interacts with neural pathways responsible for processing motivation-related stimuli. In ...
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NAD+ Research A large number of animal and human studies have been conducted on the potential applications of NAD+. Here are some relevant findings: NAD+ Anti-Aging Many people are looking for anti-aging secrets, and a study found that nicotinamide adenine dinucleotide (NAD+) levels decline with age, which may cause cell damage and may shorten lifespan. NAD+ acts as an enzyme cofactor and substrate for a variety of regulatory proteins in many important biological pathways. A large number of studies have shown that increasing NAD+ levels in tissues or cells can slow the aging process. The safety and efficacy of NAD+ have been clinically studied. There is evidence that supplementing NAD+ precursors or inhibiting NAD+ degradation may enhance metabolic activity. Studies have shown that supplementing NAD+ precursors can slow the aging process in mice. To date, the anti-aging properties of NAD+ have not been confirmed in humans. The role of NAD+ in neurodegenerative diseases Several articles mentioned that NAD+ depletion has been observed in both normal and accelerated aging. Neurodegeneration is seen in several accelerated aging dis ...
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Description N-Acetyl Selank Amidate (commonly referred to as NA Selank) is a modified version of the peptide Selank. In recent years, it has received much attention for its potential anxiolytic, nootropic, and anti-inflammatory properties. NA Selank Amidate has been extensively studied in laboratory settings for its effects on anxiety, cognitive function, and neuroprotection. Structure and Modifications NA Selank Amidate is a modified version of Selank with the addition of an acetyl group to the N-terminus of the peptide chain and an amide group to the C-terminus. These modifications work together to enhance the overall stability and bioavailability of the peptide, increase its potential for use in biological studies, and theoretically enhance its potential to cross the blood-brain barrier and increase its interaction with neurotransmitters. The amino acid sequence of NA Selank Amidate is Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-NH2. Pharmacokinetics and Pharmacodynamics NA Selank Amidate has been modified to have a longer half-life than the base Selank form, meaning it remains active longer. This is primarily due to its increased stability against degradation by enzymes and other factors. The peptide has been ...
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What is Mazdutide? Mazdutide 10MG, commonly referred to as a multi-agonist peptide, is an investigational compound being studied for its potential benefits in obesity and blood sugar management. Similar to compounds such as tirzepatide and semaglutide, mazdutide is known for its high efficacy. Researchers believe that it may significantly enhance weight loss when combined with a proper diet and exercise regimen. Additionally, studies are exploring its effects on metabolic regulation and conditions such as hypertension. How does Mazdutide work? Mazdutide stands out in obesity research due to its multifaceted mechanism of action: • Multi-receptor agonist Mazdutide targets multiple receptors involved in regulating metabolism. This action slows gastric emptying, lowers post-meal blood sugar levels, and promotes satiety. As a result, it can reduce food intake and improve energy balance. • Enhances satiety By acting on the satiety center of the brain, mazdutide helps reduce appetite and prolong feelings of fullness. This can reduce calorie intake and support weight loss efforts. • Glucose Optimization Mazdutide slows gastric emptying and regulates the release o ...
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What is LL-37? LL-37, also known as CAP-18 (tensin-activated antimicrobial protein 18), is an antimicrobial peptide expressed in nearly all tissues and organs. It is produced by many cell types, including macrophages, airway epithelial cells, skin and ocular epithelial cells, and natural killer (NK) cells. Since its discovery in 1995, LL-37 has been studied in a number of ways. These studies have shown that LL-37 has anticancer effects in colon and gastric cancer. This natural peptide may also modulate the development of inflammatory and autoimmune diseases. LL-47 has been reported to exert a protective effect in a mouse model of collagen-induced arthritis. It has also been found to kill gram-negative bacteria through direct antimicrobial activity as well as regulation. In addition, it has been shown to promote wound closure in lung disease. LL-37 has also been shown to downregulate signaling of specific Toll-like receptors (TLRs), thereby reducing the production of pro-inflammatory cytokines. It also exhibits anti-inflammatory effects, primarily by blocking signaling in Gram-negative bacteria. The following are the functions that LL-37 has been shown to have: Re ...
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What is Kisspeptin-10? Kisspeptin-10 is an isoform of kisspeptin, the protein that controls your reproductive hormones. It performs essentially the same functions as its parent protein but has a different amino acid sequence. For instance, it has 10 amino acids compared to kisspeptin’s 145. Kisspeptin-10 is processed from Kisspeptin-54, another kisspeptin variant. Research has shown that it has a quicker onset of action than the longer kisspeptin isoform. While both isoforms have similar bioavailability, Kisspeptin-10 appears to have a shorter half-life. In clinical studies, Kisspeptin-10 was found to increase luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone in men. The peptide was also shown to stimulate gonadotropin release in women during the pre-ovulatory phase of the menstrual cycle. Kisspeptin-10 has also been shown to reactivate the hypothalamic-pituitary-gonadal axis in women with chronic amenorrhea, a condition characterized by missing one or more menstrual periods. The kisspeptin peptide induced a significant increase in LH and FSH levels. How Does Kisspept ...
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What is IGF-1 LR3? IGF-1, or insulin-like growth factor, is a potent growth factor found in mammalian blood. This peptide manages and regulates growth hormone (GH) levels. IGF-1 LR3 is the abbreviated form of IGF-1, which some researchers consider to be the most potent growth factor. IGF-1 LR3 is a chemically altered amino acid chain of 83 amino acids. At position 3 on the chain, Glu(E) is replaced by Arg(R), resulting in the name LR3. This substitution at position 3 prevents IGF-1 from binding to proteins, thereby extending its half-life. Possible Applications of IGF-1 LR3 Insulin-like growth factors have been extensively studied and tested clinically. Below we will highlight some potential future research implications of IGF-1 LR3, known as IGF-binding protein. Possible Promotion of Cell Division Like IGF-1, IGF-1 LR3 is a potential potent stimulator of cell proliferation and division. Its main potential effects are thought to be on connective tissues such as muscle and bone. But it may also promote cell division in kidney, liver, skin, nerve, lung, and blood tissue. Of note, studies have shown that IGF-1 LR3 and all IGF-1 derivatives do not promot ...
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HMG (Human Menopausal Gonadotropin) – Product Information HMG, also known as human menopausal gonadotropin, was originally formulated to help women get pregnant. It is considered a fertility drug chemical that stimulates the secretion of follicle stimulating hormone (FSH) and luteinizing hormone (KH) in women, thereby increasing the chances of ovulation. On the other hand, the use of HMG has changed and is currently being studied for its potential effects on testosterone production in men. Ultimately, HMG can help users increase muscle mass and ultimately improve sexual health. Specific reproductive health centers can provide training on how to use HMG for female subjects. Although HMG for sale can provide the benefits listed above, we should not consider this experimental chemical a very successful drug. What is HMG？ H uman menopausal gonadotropin (HMG) is being studied experimentally as a treatment for female fertility issues. This experimental drug is excreted in the urine of postmenopausal women. It is also known as gonadotropin. It contains follicle stimulating hormone (FSH) and luteinizing hormone (LH), which help healthy ovaries produce eggs. ...
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What is Hexarelin? Hexarelin is a synthetic hexapeptide that mimics ghrelin, the body’s natural gut hormone. It acts on the growth hormone secretagogue receptor (GHS-R) to trigger the release of growth hormone . The growth hormone release resulting from hexarelin treatment can improve the body’s ability to produce collagen, repair ligaments and tendons, grow muscle fibers, reduce visceral body fat, and increase bone density . While hexarelin is a ghrelin analog, studies have found that hexarelin is a superior alternative to ghrelin therapy because of its potency and stability, particularly as a cardioprotective agent. The administration of hexarelin has also been shown to provide neuroprotective benefits such as promoting the growth of new brain cells, protecting healthy brain cells, and reducing inflammation in the brain. Hexarelin Benefits and Uses Hexarelin is frequently sought out for its marked effects on fat loss and muscle-building. Its ability to affect insulin sensitivity, energy production, and lean muscle growth makes it an attractive compound for researchers wishing to enhance the body composition of their subjects. Hexarelin for Fat Reduction ...
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What does the hCG hormone do? Human chorionic gonadotropin is a hormone that is primarily produced by the syncytiotrophoblast cells of the placenta during pregnancy. The hormone stimulates the corpus luteum to produce progesterone to maintain the pregnancy. The pituitary gland, liver, and colon also produce small amounts of hCG What does hCG do for men? For men or adolescent boys, HCG helps with testosterone and sperm production. HCG is also used to treat boys with cryptorchidism, a specific testicular birth problem. All About HCG Levels During Pregnancy | What is hCG? If the hCG level is below 5 mIU/mL, it is considered not to be pregnant, and if it is above 25 mIU/mL, it is considered to be pregnant. If the hCG level is between 6 and 24 mIU/mL, it is in the gray area and you may need to retest to see if the level rises to confirm pregnancy. Are there any side effects of hCG? This medicine can cause ovarian hyperstimulation syndrome (OHSS), which can be life-threatening. If you experience symptoms such as bloating, diarrhea, severe nausea, stomach pa ...
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L-Glutathione Overview L-Glutathione, also known as GSH, is a tripeptide composed of the amino acids glycine, cysteine, and glutamic acid. It is synthesized by the liver and plays a role in multiple bodily functions such as tissue regeneration, chemical and protein production, and immune system support. Glutathione acts as a powerful antioxidant, shielding cells from harm caused by free radicals and reactive oxygen species. It is present in various organisms, including plants, animals, fungi, bacteria, and archaea. Glutathione is a Powerful Antioxidant . Glutathione (GSH) is a powerful antioxidant that is found in every cell of the body. It helps stave off the impact of oxidative stress, which may, in turn, reduce the risk of developing diseases such as diabetes, cancer, and rheumatoid arthritis. It can act directly as an antioxidant to protect cells against free radicals and pro-oxidants. GSH is involved in multiple cellular processes including protein folding, safeguarding protein thiols from oxidation and crosslinking, breaking down proteins with disulfide bonds, regulating cell cycle and proliferation, metabolizing ascorbate, inducing apoptosis, and promoting ferrop ...
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GHK-Cu (Copper Peptide) Overview GHK-Cu, also known as copper peptide GHK-Cu, is a naturally occurring copper complex of the tripeptide glycyl-L-histidyl-L-lysine. It was first isolated from human plasma and has since been found in other areas of the body, such as saliva and urine. Copper peptides are naturally occurring protein fragments that have a strong attraction to copper ions and are thought to play a vital role in the normal functioning of the body. GHK-Cu has been the subject of numerous studies, which have revealed several roles and benefits in the human body. GHK-Cu and Wound Healing GHK-Cu has been shown to improve the healing of ischemic open wounds in rats, leading to faster healing. It stimulates the synthesis of collagen, elastin, and glycosaminoglycans in the skin, which are essential for wound healing. In the same study, wounds treated with GHK-Cu showed a decreased concentration of metalloproteinases 2 and 9, which are enzymes involved in the breakdown of extracellular matrix during the wound healing process . GHK-Cu stimulates collagen and decorin production, which are essential for tissue regeneration and wound healing. It also increases cel ...
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What is Epitalon (Epithalon) Peptide? Epitalon , also known as Epithalon or Epithalone, is a synthetic version of a naturally occurring polypeptide called Epithalamine, which is produced in the pineal gland. This tetrapeptide, consisting of four amino acids bound together, plays a significant role in the body’s ability to combat aging and promote rejuvenation. Discovered by Russian scientists Vladimir Khavinson and Vladimir Anisimov, Epitalon has been the subject of numerous studies, primarily focusing on its potential to extend lifespan and improve health by stimulating the production of telomerase, an enzyme that aids in the maintenance and repair of telomeres. Epitalon and Telomere Length Epitalon is a synthetic peptide known for its potential to influence the aging process by affecting telomeres, the protective caps at the ends of chromosomes. Research has shown that Epitalon can stimulate the production of telomerase, an enzyme that plays a key role in maintaining and extending telomeres. This process is crucial because as cells divide, telomeres naturally shorten, leading to aging and eventual cell death. By promoting telomerase activity, Epitalon may help to e ...
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DSIP Research Overview Delta Sleep-Inducing Peptide (DSIP) is a peptide with a molecular weight of 850 daltons. It has the amino acid motif: N-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-C. DSIP plays various roles, such as endocrine regulation, disease and medicine, and sleep induction. However, the connection between DSIP and sleep is not fully understood due to the lack of isolation of the DSIP gene, protein, and potential receptor. Research has been conducted on the effectiveness of DSIP in treating insomnia, pain, and withdrawal. DSIP has shown the ability to counteract opiate receptors, leading to a significant reduction in opioid and alcohol dependence. Clinical trials are currently underway to explore its potential in treating withdrawal syndrome. Additionally, DSIP has been found to alleviate narcolepsy and restore disrupted sleep patterns in certain studies DSIP Structure delta Sleep-indu c ing peptide phosphate 70754-23-3 (2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]acetyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-3-pho ...
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Uses: Growth hormone releasing peptide-6 can promote the secretion of growth hormone, regulate food intake, increase body weight and promote animal growth. Product Description Hexapeptide-2 reduces the production and distribution of melanin to keratinocytes, brightens the skin, fights dark spots and hyperpigmentation, and evens out skin tone. Plus, it reduces the appearance of fine lines and wrinkles. Hexapeptide-2 is a safe and useful ingredient for after-sun repair, skin lightening and anti-aging skin care applications. It can be used in whitening cream, skin color balance and brightening products.Hexapeptide-2 can reduce the aging level of cells by inhibiting the activity of β-galactosidase, such as the reduction of collagen synthesis. Therefore, hexapeptide-2 also has anti-aging and anti-wrinkle effects. About us ...
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Overview : Cagrilintide is a synthetic amylin analog specifically designed for advanced preclinical research studies focused on metabolic disorders and glucose regulation . This peptide provides researchers with a valuable tool to study amylin’s role in glucose homeostasis and appetite regulation , offering important insights into metabolic conditions such as diabetes and obesity . Product Specifications : Purity : >99% (HPLC verified) Formulation : Lyophilized powder, optimized for reconstitution Molecular Formula : C₁₉₄H₃₁₂N₅₄O₅₉S₂ Molecular Weight : ~4500 g/mol CAS Number : 1415456-99-3 PubChem CID : 167312356 Research Applications : Cagrilintide is widely utilized in preclinical research models investigating the following areas: Amylin and Blood Glucose Regulation : Investigating how amylin affects glucose homeostasis in r ...
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Key Benefits of BPC-157: Accelerated Healing: BPC-157 has demonstrated remarkable properties in accelerating the healing of various tissues, including muscles, tendons, ligaments, and even the gastrointestinal tract. This makes it a potential asset for individuals recovering from injuries or surgeries. Anti-Inflammatory Effects: The peptide exhibits strong anti-inflammatory properties, helping to reduce inflammation in different parts of the body. This anti-inflammatory effect can contribute to pain relief and improved mobility in individuals with conditions such as arthritis or sports-related injuries. Joint Health: Studies suggest that BPC-157 may play a role in supporting joint health by promoting the repair and regeneration of connective tissues. This can be particularly beneficial for athletes and those with joint-related issues. Gastrointestinal Support: BPC-157 has been researched extensively for its positive effects on the gastrointestinal tract. It may aid in the healing of ulcers, improve gut integrity, and support overall digestive health. Neuroprotective Properties: Some studies suggest that BPC-157 may have neuroprotective effects, potentia ...
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Class of Compound: Peptide ARA-290 Research ARA-290 is a variant of erythropoietin, engineered to selectively interact with the innate repair receptor. This peptide has been shown to decrease inflammatory pathways and promote tissue protection without the hematopoietic effects associated with erythropoietin. Research indicates that ARA-290 can help reduce HbA1c levels, improve cholesterol profiles, modulate neuropathic pain, and stimulate wound repair. ARA-290 and Tissue Repair ARA-290’s interaction with the innate repair receptor facilitates tissue protection and repair by antagonizing inflammatory processes. This action has been observed in preclinical models of neuropathy, where ARA-290 reduced allodynia and promoted healing. These properties make it a promising candidate for further research into therapies targeting tissue damage and inflammation . ARA-290 and Metabolic Control Studies have demonstrated that ARA-290 can improve metabolic control in patients with type 2 diabetes. In a clinical trial, subjects receiving ARA-290 showed signific ...
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