NA SELANK AMIDATE

PEPTIDES

Selank is a short, synthetic analogue of tuftsin. It has profound anti-anxiety properties. Selank also boosts memory and learning and has been shown to have beneficial effects on pain perception

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Description

N-Acetyl Selank Amidate (commonly referred to as NA Selank) is a modified version of the peptide Selank. In recent years, it has received much attention for its potential anxiolytic, nootropic, and anti-inflammatory properties. NA Selank Amidate has been extensively studied in laboratory settings for its effects on anxiety, cognitive function, and neuroprotection.

Structure and Modifications
NA Selank Amidate is a modified version of Selank with the addition of an acetyl group to the N-terminus of the peptide chain and an amide group to the C-terminus. These modifications work together to enhance the overall stability and bioavailability of the peptide, increase its potential for use in biological studies, and theoretically enhance its potential to cross the blood-brain barrier and increase its interaction with neurotransmitters. The amino acid sequence of NA Selank Amidate is Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-NH2.

Pharmacokinetics and Pharmacodynamics
NA Selank Amidate has been modified to have a longer half-life than the base Selank form, meaning it remains active longer. This is primarily due to its increased stability against degradation by enzymes and other factors. The peptide has been studied for modulating the expression of certain genes involved in neurotransmission, particularly in the hippocampus and limbic reticular complex regions, which are parts of the brain that are critical for both learning and memory.

Antianxiety and Anti-inflammatory Effects

NA Selank Amidate's antianxiety effects are the focus of clinical research on the peptide. This includes reducing anxiety and stress responses, as well as improving mood. It has also been shown to have potent anti-inflammatory properties, including helping to reduce inflammation in the brain and other tissues. The mode of action for these effects is thought to be due to its ability to modulate the expression of genes involved in immune responses and neurotransmission.

Comparison with NA Semax Amidate
NA Semax Amidate is a similar modified version of Semax. NA Selank Amidate and NA Semax Amidate are similar in structure and modification, but they are studied for different effects. NA Selank Amidate is often studied for its anxiolytic and anti-inflammatory effects, while NA Semax Amidate is primarily studied around cognition and neuroprotection. In summary, NA Selank Amidate is a modified version of Selank with enhanced stability and bioavailability that is studied for its anxiolytic, nootropic, and anti-inflammatory properties. Its modifications make it a promising peptide for further research in these areas.

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