Methyltrienolone (Oral tren)

STEROIDS

Metribolone is an anabolic androgenic steroid (AAS) or AR agonist with both anabolic and androgenic activity.

12345@Ursofik.com

Description

Information about Metribolone

Metribolone, chemically known as Mmethyltrienolone, is a synthetic, orally active anabolic androgenic steroid (AAS) derivative of 17α-alkylated nandrolone (19-nortestosterone) that has never been marketed for human use but has been used extensively in research and underground bodybuilding.

Investigated as a thermal ligand in androgen receptor (AR) ligand binding assays (LBAs) and as a photoaffinity label for the AR. More precisely, Metribolone is a 17α-methylated derivative of Trenbolone. It was briefly studied in the late 1960s and early 1970s for the treatment of advanced breast cancer in women, but was found to cause signs of severe hepatotoxicity at very low doses, so development of the drug was discontinued.

Metribolone Pharmacology

Metribolone is an anabolic androgenic steroid (AAS) or AR agonist with both anabolic and androgenic activity. It is one of the most potent AAS synthesized to date, with oral anabolic activity 120 to 300 times that of the reference AAS methyltestosterone and androgenic activity 60 to 70 times that of the reference AAS methyltestosterone in ovariectomized male rats, although the same level of effectiveness has not been established.

In addition to the AP (anabolic receptor), metrolone has a high affinity for the progesterone receptor (PR) and also binds to the glucocorticoid receptor (GR).

The drug was also identified in 2007 as a potent antimineralocorticoid, with similar affinity to aldosterone and spironolactone for the mineralocorticoid receptor.

In addition, metribolone was identified in 2010 as a potent inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD) 1 and 2 (IC50 0.02 and 0.16 μM, respectively).

Based on this finding, some say that methibolone should be used very cautiously in studies, taking into account 3β-HSD inhibition to avoid misinterpretations. Similar to other 17α-alkylated AAS, Metribolone has a high hepatotoxic potential.

However, the hepatotoxic potential of methoxybolone appears to be extremely high, probably related to its extremely high efficacy and metabolic stability; in a study of this drug in the treatment of advanced breast cancer, liver dysfunction was observed at low doses.

We have cooperated with experienced shipping forwarders for many years, they arrange the shipment. No matter by express, by air or by sea, we will track the course of the goods all the way, to make sure goods arrive at you on time and in good condition.

Previous
S23

Next
Epistane

GET A QUOTE

Whether you have any questions about our products, please feel free to contact us, we will reply as soon as possible.

Melanotan 2

Mechanism of Action: Melanotan II is an agonist of melanocortin receptors 1 and 4 (MC-1R and MC-4R), which respectively regulate melanin production and male erectile function. It is also believed to stimulate MC-3R, which affects appetite and energy levels. Notable Studies: · Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study · Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan 2 · An unhealthy glow? A review of Melanotan use and associated clinical outcomes What is Melanotan 2? Melanotan 2 is a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH). The molecule was first developed in the 1980s by University of Arizona researchers, who were looking to clarify the nature and role of the melanocortin receptors in physiological functions. Namely, the peptide was intended to be used as a sunless tanning agent, but was subsequently found to strongly affect sexual function and appetite . Melanotan 2 (MT-II) should not be confused with another ...

TB-500

What is TB-500? TB-500 is a 43 amino acid synthetic analog of thymosin B-4 (TB-4), which occurs naturally in nearly all mammalian cells. TB-500 is known for its effects on actin, cell migration, and wound healing. Animal models and in vitro studies have shown that TB-500 can improve blood vessel growth, accelerate wound healing, reduce inflammation, and promote production of extracellular matrix. The peptide is currently being studied for its ability to reduce oxidative stress in spinal cord injuries, improve recovery after heart attacks, and have a variety of anti-aging effects. TB-500 Mechanism of Action TB-500 is the active domain of TB-4 and primarily acts as an actin-binding protein. Actin is an important component of cellular structure and makes up microfilaments. Microfilaments are responsible for giving cells their shape, protecting the integrity of cell membranes, allowing cells to move/migrate, and certain steps in cell reproduction. Actin is also one of the main components of muscle protein. Without actin, muscles cannot contract. Actin-binding proteins such as TB-4 sequester actin monomers (single units of actin), thereby protecting them from degradation and allowing them to polymerize into microfi ...

OXYTOCIN

What is oxytocin? The peptide hormone is made up of 9 amino acids. It is produced in the hypothalamus, an area of the brain that controls heart rate, blood pressure, and digestion. OT is released into the bloodstream by the posterior pituitary gland. Oxytocin was discovered by Sir Henry Dale in 1996. He found that extracts from the posterior pituitary gland of humans caused the uterus of pregnant cats to contract. Sir Henry Dale also coined the name oxytocin, which means "quick labor" in Greek. This peptide hormone controls many functions. It has an impact on labor, milk secretion during breastfeeding, and bonding with newborns in humans. It also plays an important role in sexual arousal, romantic attachment, and other social interactions. It is also known as the "love hormone." A 2012 study found that levels of this hormone were significantly higher in newly-in-love people than in singles. The findings suggest that it may play an important role in the initial stages of a relationship. Pure Rawz sells this product for research use only. How does oxytocin work? Research suggests that it interacts with neural pathways responsible for processing motivation-related stimuli. In particular, ...

IPAMORELIN

Compound Class: Peptide Mechanism of Action: Ipamorelin is a selective growth hormone secretagogue and ghrelin receptor agonist that triggers and stimulates growth hormone production by mimicking ghrelin. It binds to ghrelin receptors, stimulating growth hormone release, and inhibits somatostatin and suppresses its effects. Notable Studies: · Ipamorelin, the first selective growth hormone secretagogue · The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced reductions in bone formation in adult rats · The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats What is ipamorelin? Ipamorelin is a laboratory-made compound known as growth hormone-releasing peptide. It stimulates the body to release growth hormone, which promotes systemic growth of muscle, bone, vascular system, and other cells and body tissues. Ipamorelin is unique among growth hormone-releasing peptides in that, unlike most growth hormone-releasing peptides, it does not activate the body's natural stress response. This gives ipamorelin an advantage over similar compounds. However, researc ...

MOTS-C

Class of Compound: Peptide Mechanism of Action: While the precise mechanism of action of MOTS-c is currently under investigation, it is hypothesized that its metabolic effects are mediated through its translocation to the nucleus and subsequent activation of AMPK. Notable Studies: · MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction. · The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. · MOTS-c Functionally Prevents Metabolic Disorders. Metabolites. What is MOTS-c? MOTS-c , is a mitochondrial-derived peptide, consisting of 16 residues encoded by the 12S rRNA region of the mitochondrial genome. This means that the genetic information that is translated into the peptide’s amino acid sequence has not been processed into a strip of mRNA. Rather, the peptide is translated from a strand of rRNA whose main role is not to carry genetic information but to help ribosomes work in processing such information. MOTS-cwas discovered in 2015 and has s ...

We Provide Best Services
Agent

Email For Us

Call For Us

Methyltrienolone (Oral tren)

12345@Ursofik.com

Previous
S23

Next
Epistane

GET A QUOTE

Categories

Hot products

Melanotan 2

TB-500

OXYTOCIN

IPAMORELIN

MOTS-C

New Products

Follow Us

Useful Link

Products

Newsletter

Contact Us

Methyltrienolone (Oral tren)

S23

Epistane

GET A QUOTE

Related products

Categories

Hot products

New Products

Useful Link

Products

Contact Us

GET IN TOUCH!