RAD 140

POWDER

SARMs RAD 140, also known as Testolone, is one of several selective androgen receptor modulators (SARMs) that was initially developed as a potential alternative to testosterone replacement therapy.

12345@Ursofik.com

Inquire Now

Description

SARMS RAD 140

SARMs RAD 140, also known as Testolone, is one of several selective androgen receptor modulators (SARMs) that was initially developed as a potential alternative to testosterone replacement therapy. It should not be confused with it’s esterified form, RAD 150, also known as TLB 150.

RAD 140 binds to the androgen receptors (AR) in a selective manner and does not produce the full range of androgenic effects as similar substances like testosterone, DHT, or anabolic steroids.

RAD 140 Benefits from Clinical Research

Muscle Growth: A study on young male cynomolgus monkeys investigated the anabolic effects of 28 days of RAD140 at a dosage of 0.01mg/kg, 0.1mg/kg, and 1mg/kg per day. A mean weight gain of 10% was observed in both the 0.1mg/kg/day group and the 1mg/kg/day group, indicating a quantity response curve that leveled off and provided no additional benefit with higher quantities.

There was no consistent effect on body fat mass in either group, however muscle mass increased in the 0.1 and 1mg/kg/day groups. No significant increases in liver enzymes or prostate weight were reported in either group suggesting a high level of selectivity for androgen receptors in muscle tissue.

Neuroprotection: Androgens have shown clinical significance in preventing neuronal apoptosis and improving cognitive function in Alzheimer’s Disease (AD), primarily through a nongenomic mechanism of the Androgen Receptor (AR). Rapid phosphoinositide 3-kinase/Akt signaling, activated by androgens, regulates the expression of proteins linked to apoptosis such as bax, seladin 1, survivin, XIAP, and bcl-xl.

Androgens can also maintain the integrity of neurons and thus improve cognitive function. Studies have shown that Aβ impairs synaptic structure and function of hippocampal neurons which is reversed by androgen administration resulting in improved cognitive performances in AD animal models. Although the underlying exact mechanisms are not yet fully understood, androgen’s action of inhibiting Aβ-induced apoptosis appears to play a role.

Cellular Protection: A 2014 study investigated the neuroprotective effects of RAD140 on cultured neurons and male rats that were lesioned with kianate. The experiment included two parts – one in vitro involving cell cultures and another in vivo through animal testing.

Results from the in vitro study showed that RAD140 was able to prevent cell death and restore mitochondrial membrane potential, indicating that it could offer neuroprotection much like testosterone and other androgens investigated for these effects.

The in vivo experiment tested the efficacy of RAD140 on male rats with kainate-induced seizures and showed a significant reduction in seizure activity compared to controls. Overall, this study demonstrated that RAD140 is capable of offering neuroprotection both in vitro and in vivo, suggesting it may one day have a place in treating neurological disorders.

Side effects of RAD 140

While RAD 140 and other SARMs do not cause androgenic side effects to the same extent as anabolic steroids like Testosterone, reports have revealed the potential for nausea, aggression, reduction in natural testosterone levels, or mild male pattern hair loss from the use of RAD 140. A single-member case report indicated drug-induced liver injury after 11 months of the use of an anti-depressant, as well as intermittent use of RAD 140 and LGD-4033.

We have cooperated with experienced shipping forwarders for many years, they arrange the shipment. No matter by express, by air or by sea, we will track the course of the goods all the way, to make sure goods arrive at you on time and in good condition.

Previous
GW501516

Next
LGD4033

GET A QUOTE

Whether you have any questions about our products, please feel free to contact us, we will reply as soon as possible.

Melanotan 2

Mechanism of Action: Melanotan II is an agonist of melanocortin receptors 1 and 4 (MC-1R and MC-4R), which respectively regulate melanin production and male erectile function. It is also believed to stimulate MC-3R, which affects appetite and energy levels. Notable Studies: · Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study · Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan 2 · An unhealthy glow? A review of Melanotan use and associated clinical outcomes What is Melanotan 2? Melanotan 2 is a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH). The molecule was first developed in the 1980s by University of Arizona researchers, who were looking to clarify the nature and role of the melanocortin receptors in physiological functions. Namely, the peptide was intended to be used as a sunless tanning agent, but was subsequently found to strongly affect sexual function and appetite . Melanotan 2 (MT-II) should not be confused with another ...

TB-500

What is TB-500? TB-500 is a 43 amino acid synthetic analog of thymosin B-4 (TB-4), which occurs naturally in nearly all mammalian cells. TB-500 is known for its effects on actin, cell migration, and wound healing. Animal models and in vitro studies have shown that TB-500 can improve blood vessel growth, accelerate wound healing, reduce inflammation, and promote production of extracellular matrix. The peptide is currently being studied for its ability to reduce oxidative stress in spinal cord injuries, improve recovery after heart attacks, and have a variety of anti-aging effects. TB-500 Mechanism of Action TB-500 is the active domain of TB-4 and primarily acts as an actin-binding protein. Actin is an important component of cellular structure and makes up microfilaments. Microfilaments are responsible for giving cells their shape, protecting the integrity of cell membranes, allowing cells to move/migrate, and certain steps in cell reproduction. Actin is also one of the main components of muscle protein. Without actin, muscles cannot contract. Actin-binding proteins such as TB-4 sequester actin monomers (single units of actin), thereby protecting them from degradation and allowing them to polymerize into microfi ...

OXYTOCIN

What is oxytocin? The peptide hormone is made up of 9 amino acids. It is produced in the hypothalamus, an area of the brain that controls heart rate, blood pressure, and digestion. OT is released into the bloodstream by the posterior pituitary gland. Oxytocin was discovered by Sir Henry Dale in 1996. He found that extracts from the posterior pituitary gland of humans caused the uterus of pregnant cats to contract. Sir Henry Dale also coined the name oxytocin, which means "quick labor" in Greek. This peptide hormone controls many functions. It has an impact on labor, milk secretion during breastfeeding, and bonding with newborns in humans. It also plays an important role in sexual arousal, romantic attachment, and other social interactions. It is also known as the "love hormone." A 2012 study found that levels of this hormone were significantly higher in newly-in-love people than in singles. The findings suggest that it may play an important role in the initial stages of a relationship. Pure Rawz sells this product for research use only. How does oxytocin work? Research suggests that it interacts with neural pathways responsible for processing motivation-related stimuli. In particular, ...

IPAMORELIN

Compound Class: Peptide Mechanism of Action: Ipamorelin is a selective growth hormone secretagogue and ghrelin receptor agonist that triggers and stimulates growth hormone production by mimicking ghrelin. It binds to ghrelin receptors, stimulating growth hormone release, and inhibits somatostatin and suppresses its effects. Notable Studies: · Ipamorelin, the first selective growth hormone secretagogue · The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced reductions in bone formation in adult rats · The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats What is ipamorelin? Ipamorelin is a laboratory-made compound known as growth hormone-releasing peptide. It stimulates the body to release growth hormone, which promotes systemic growth of muscle, bone, vascular system, and other cells and body tissues. Ipamorelin is unique among growth hormone-releasing peptides in that, unlike most growth hormone-releasing peptides, it does not activate the body's natural stress response. This gives ipamorelin an advantage over similar compounds. However, researc ...

MOTS-C

Class of Compound: Peptide Mechanism of Action: While the precise mechanism of action of MOTS-c is currently under investigation, it is hypothesized that its metabolic effects are mediated through its translocation to the nucleus and subsequent activation of AMPK. Notable Studies: · MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction. · The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. · MOTS-c Functionally Prevents Metabolic Disorders. Metabolites. What is MOTS-c? MOTS-c , is a mitochondrial-derived peptide, consisting of 16 residues encoded by the 12S rRNA region of the mitochondrial genome. This means that the genetic information that is translated into the peptide’s amino acid sequence has not been processed into a strip of mRNA. Rather, the peptide is translated from a strand of rRNA whose main role is not to carry genetic information but to help ribosomes work in processing such information. MOTS-cwas discovered in 2015 and has s ...

We Provide Best Services
Agent

Email For Us

Call For Us

RAD 140

12345@Ursofik.com

Previous
GW501516

Next
LGD4033

GET A QUOTE

Categories

Hot products

Melanotan 2

TB-500

OXYTOCIN

IPAMORELIN

MOTS-C

New Products

Follow Us

Useful Link

Products

Newsletter

Contact Us

RAD 140

GW501516

LGD4033

GET A QUOTE

Related products

Categories

Hot products

New Products

Useful Link

Products

Contact Us

GET IN TOUCH!